"Cowtown's bison blacksmith!"
 
Like many cartoons during its time, Wild West C.O.W.-Boys of Moo Mesa dealt
with a mutation of some kind. In this case, an irradiated comet struck the late 19th century Western plains creating a miles high mesa shrouded in clouds. Everything trapped on top of the mesa was "cow-metized" by the light from the "cow-met" and "evolved" into a "bovipomorphic" state.
Inspired by old tales of the Wild West, this new bovine community developed to the point where they emulated that era's way of life, including the requisite ruffians and corrupt sheriffs.
The concepts of steampunk and Weird West were utilized throughout its run.